Development of Doxorubicin – Adsorbed Magnetic Nanoparticles Modified with Biocompatible Copolymers for Targeted Drug Delivery in Lung Cancer

Iron oxide nanoparticles are smart materials that have been commonly used in medicine for diagnostic imaging, drug delivery, and therapeutic applications. In this study, Iron oxide nanoparticles and doxorubicin hydrochloride, were absorbed into poly (D, L-lactic-co-glycolic acid) poly (ethylene glycol) (PLGA-PEG) nanoparticles for narrow behavior. PLGA:PEG triblock copolymers were synthesized by ring-opening polymerization of D, L-lactide and glycolide with polyethylene glycol (PEG3000) as an initiator. The bulk properties of these copolymers were characterized using Fourier transform infrared spectroscopy. In adding together, the consequential particles were characterized by scanning electron microscopy, x-ray powder diffraction, and vibrating sample magnetometry. The drug adsorbed efficiency achieved for Fe3O4 magnetic nanoparticles modified with PLGA:PEG3000 copolymers was 70%, and the release profile were controlled. The in vitro cytotoxicity test showed that the Fe3O4-PLGA:PEG3000 magnetic nanoparticles had no cytotoxicity. There is potential for apply of Fe3O4-PLGA:PEG3000 magnetic nanoparticles for biomedical purpose.